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Chemotherapy spurs awakening, but senolytic drugs may prevent relapse

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Chemotherapy awakens dormant disseminated tumor cells in lung. Credit: Prof. Hu Guohong’s group

Breast cancer often relapses in distant organs even when complete regression of primary tumors is achieved after initial treatment. Dormant and persistent disseminated tumor cells (DTCs) have been observed in animals with non-metastatic disease, which cannot be targeted by systemic chemotherapy.

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