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New human ‘multi-zonal’ liver organoids improve injury survival in rodents

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Engineering hiPS cell-derived mZ-HLOs. Credit: Nature (2025). DOI: 10.1038/s41586-025-08850-1

One reason why our livers excel at clearing waste from our blood system is that the organ functions according to three key “zones” that perform specific major tasks. So, if scientists hope to create self-growing patches of liver organoid tissue that could…

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