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DNA repair enzyme Polβ shields developing brain from harmful mutations, study reveals

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Polβ-dependent DNA demethylation is essential for neuronal development. During neuronal development, DNA demethylation at enhancer regions is required to activate gene expression. In the absence of DNA polymerase β (Polβ), indel mutations near CpG sites increase approximately ninefold, highlighting the critical role of Polβ in…

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