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Mechanisms of antibody gene diversification during somatic hypermutation

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AID-induced U/G lesions can be perfectly repaired or may result in C/G transition mutations via DNA replication, C/G transition or transversion mutations via the BER pathway, and A/T mutations via the MMR pathway. Credit: Science China Press

In a recent online publication in Science China Life Sciences, researchers from the laboratory of Leng-Siew Yeap at the Shanghai Institute of Immunology,…

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