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First mouse strain susceptible to severe COVID-19 without the need for genetic modification identified

December 7, 2024

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Out of these eight strains of mice, only the CAST mouse was susceptible to SARS-CoV-2, including beta, omicron and delta variants. The eight strains include A/J, B6J, CAST, 129S1, NSG, NZO, PWK, and WSB, encompassing traits like type 1 and type 2 diabetes susceptibility, obesity, and leanness. While other strains either recovered or showed mild symptoms, the CAST mice displayed acute illness, highlighting their unique…

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First mouse strain susceptible to severe COVID-19 without the need for genetic modification identified

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