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Why are older women predisposed to osteoarthritis?

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A drop in estradiol and progesterone may explain the increased risk of osteoarthritis after menopause, a mouse study suggests. Image credit: Hollie Fernando/Getty Images.
  • Menopause is one risk factor for osteoarthritis.
  • One recent study in mice uncovered that menopause led to a drop in 17beta-estradiol and progesterone, which increased cartilage aging, degeneration, and disassembly of the extracellular matrix.
  • This research opens up the door for developing certain treatments for osteoarthritis….

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