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Basal cell carcinoma’s low immunogenicity linked to suppression of antigen presentation from its cell of origin

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Basal cell carcinoma has low immunogenicity. Tumor cells express Foxc1 protein (red), which suppresses HLA class I (green) in the tumor cells. Credit: Shawn Demehri, Massachusetts General Hospital

Compromised antigen presentation ranks among the top mechanisms that render cancers non-immunogenic (non-responsive to immune-based therapies). Despite harboring the highest tumor mutational burden of…

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