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Integrative exome sequencing and machine learning identify new genes contributing to systemic sclerosis risk

June 17, 2025

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Graphical abstract. Credit: Annals of the Rheumatic Diseases (2025). DOI: 10.1016/j.ard.2025.05.009

Systemic sclerosis (SSc) is a severe autoimmune disease with complex genetic causes. Some genetic contributors have been identified, but others remain unknown, which has impeded development of targeted treatments. In a new…

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Integrative exome sequencing and machine learning identify new genes contributing to systemic sclerosis risk

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