HomeHealth NewsInhibiting an astrocytic 'brake' that blocks spinal cord repair could pave path...

Inhibiting an astrocytic ‘brake’ that blocks spinal cord repair could pave path to neuronal regeneration

September 11, 2025

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In the spinal cord injury animal model, administration of KDS2010 suppressed the injury-induced overexpression of MAOB in astrocytes and restored the expression of MAP2, a neuronal marker protein, thereby preserving neurons at the lesion site (a). Electron microscopy further revealed that demyelinated and disrupted axons were restored to near-normal myelinated structures (b–c). Quantitative g-ratio analysis confirmed…

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