PLOS Computational Biology (2025). DOI: 10.1371/journal.pcbi.1013508″
These graphs show extracellular dopamine levels, or eda, as they vary naturally (gray) and in response to lower (blue) and higher (yellow) dosages of the drug modafinil. When taken early, during a “circadian trough,” dopamine levels spike, but sustain more steadily compared to other scenarios that include spikes followed by crashes. Credit: PLOS…
