HomeHealth NewsHIV's shape-shifting protein reveals clues for smarter drug design

HIV’s shape-shifting protein reveals clues for smarter drug design

October 25, 2025

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On the left is integrase in its “intasome” structure of four identical four-part complexes (pink) that connect to create one 16-part complex that locks around viral DNA (blue). On the right is integrase in its simpler four-part complex (pink), as it interacts with viral RNA (green) inside an HIV capsid. Credit: Salk Institute

The rate of HIV infection continues to climb globally. Around 40…

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