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Flavanols can trigger brain activity for memory and stress response

November 2, 2025

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A single oral administration of astringent FLs stimulated the central nervous system, activating the hypothalamic coricotropin-releasing hormone (CRH) neurons. The secreted CRH activated the noradrenaline (NA) neural network in the locus coeruleus (LC). The projection of NA from LC to the hypothalamus preoptic area suppresses sleep and promotes wakefulness. The projection of NA and dopamine (DA) from LC and DA from the…

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