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Caffeine blocks adenosine, the same pathway used by fast-acting depression treatments

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The coffee paradox in adenosine-mediated antidepressant action. Depression (left) and coffee consumption (right) are both linked through adenosine signaling (center), creating a pharmacological paradox: chronic coffee drinking appears protective against depression through tonic adenosine receptor modulation, while acute pre-treatment caffeine may attenuate the phasic adenosine surge required for rapid antidepressant…

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