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Computational deep dive reveals hidden cancer drug targets and repurposing opportunities

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DeepTarget’s predictions are based on the principle that removing a gene encoding the protein target of a given drug through CRISPR-Cas9 gene editing can mimic the inhibitory effects of that drug. The tool was built by leveraging large-scale genetic and drug screening experiments with comprehensive data for 1450 drugs across 371 cancer cell lines. Credit: Sanju Sinha, Sanford Burnham Prebys

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