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New insights into master regulators reveal therapeutic vulnerabilities

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A new study from the Vakoc lab reveals how tuft cell lung cancer’s master regulator, POUF23, binds to DNA and the OCA-T1 protein. The crystal structure of this three-part interface, seen here from the front and back, allows scientists to consider how and which kinds of drugs might target it. The study’s first author, former postdoc Aktan Alpsoy, is now a faculty member at Middle East Technical University. Credit: Vakoc…

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