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Inflammation-induced metabolic shifts linked to brain disorders

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This illustration depicts the experimental workflow using a mouse model of LPS-induced acute systemic inflammation and PiTMaP-based metabolomics. Metabolic profiles were compared across major brain regions—including the cerebrum, hippocampus, cerebellum, and hypothalamus—revealing that only the cerebrum showed marked metabolic alterations. Projection to latent structures-discriminant analysis highlights clear…

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