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Rb1 identified as predictive biomarker for new therapeutic strategy in some breast cancers

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These two images demonstrate synthetic lethality with a non-responsive cell line (right) compared to a responder to ATR +PKMYT1 inhibition (left). As demonstrated by the long strands, the non-responder’s DNA continues the process of replication fork progression normally, compared to the disrupted process demonstrated by the short and damaged strands. Credit: The University of Texas MD Anderson Cancer Center
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