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AI model predicts B cell reactivity to neoantigens for improved cancer vaccines

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Schematic illustration of the model that identifies B cell epitopes, DeepNeo-BCR, on the basis of the CNN architecture. Credit: Science Advances (2025). DOI: 10.1126/sciadv.adx8303

Neoantigens are unique markers that distinguish only cancer cells. By adding B cell reactivity, cancer vaccines can move beyond one-time attacks and short-term…

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