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Combination therapy for Burkitt’s lymphoma dramatically improves cure rates in mice

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Treatment schedule in an immunocompetent mouse model bearing a high burden of Burkitt’s lymphoma. While conventional CAR-T therapy alone resulted in no cures, adding five doses of a SUMOylation inhibitor led to long-term survival in 80% of the mice. Credit: Kanazawa University

Burkitt’s lymphoma is a rare and aggressive blood cancer characterized by a translocation of the MYC gene. It occurs…

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