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A new reagent makes living brains transparent for deeper, non-invasive imaging

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Three-dimensional fluorescence imaging of neurons in Layer 5 of the cerebral cortex, captured by two-photon microscopy in mice expressing a fluorescent protein (Thy1-EYFP-H). SeeDB-Live clearing improved fluorescence brightness in deep brain regions compared to uncleared tissue. Credit: Shigenori Inagaki and Takeshi Imai, Kyushu University

Making a living brain transparent and watching its…

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