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New cancer therapies target epigenetic switch

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Violin plots showing changes in RNA expression. Credit: Allis lab

Cancers emerge from many different paths. One path begins early, in embryonic development, when a protein complex called PRC2, which regulates cell differentiation, identity, and plasticity, becomes dysfunctional. PRC2 has well-established links to breast, prostate, blood, and skin cancers, among others.

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