HomeHealth NewsGLP-1s don't work for everyone: Why, and what to do?

GLP-1s don’t work for everyone: Why, and what to do?

April 16, 2026

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Combo treatment may work best for those who don’t respond to GLP-1s alone, a recent review suggests. Image credit: Lajst/Getty Images

Over the past few years, GLP-1 receptor agonists have been growing in popularity for weight loss.
While many people lose between 5-15% of their starting body weight while on a GLP-1, as much as 20% of people may not respond to the drug.
Recent research has found that a person’s genetic makeup may explain why some people do not respond to GLP-1 drugs.
A new…

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