HomeHealth NewsInflammation may trigger protective cell shift in ulcerative colitis, study finds

Inflammation may trigger protective cell shift in ulcerative colitis, study finds

June 23, 2026

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During chronic inflammation, IL-22 signaling triggers Paneth cell metaplasia in the colon. These metaplastic cells produce REG3A, an antimicrobial protein that promotes repair of the intestinal lining. Credit: Institute of Science Tokyo

Paneth cell metaplasia (PCM), long viewed as a consequence of chronic inflammation in ulcerative colitis, may also help protect and repair the intestine,…

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