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Study finds new weak spot linked to DNA repair in aggressive, drug-resistant cancers

July 28, 2026

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When the researchers led by Nanyang Technological University, Singapore treated triple-negative breast cancer cells with PARP inhibitors and chemicals that induced DNA damage, some PARP1 enzymes (in green) were found on the cells’ DNA (in blue) (left). But in cells where the TEX264 protein was blocked, more PARP1 molecules accumulated on the DNA (right). This suggests that TEX264 is involved in removing PARP1 from DNA….

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