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Solving a mysterious inflammatory fever opens the book on a much bigger story

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The molecular “handshake” breaks: a shortened form of pyrin (in green) can no longer bind to CDC42 (in magenta). Credit: Hudson Institute of Medical Research

Three research teams working independently around the world have landed on the same discovery: A single molecular “handshake” inside our cells controls a family of inflammatory diseases, including one of the most common inherited fevers on…

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