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Novel molecular shuttle could expand delivery of medicines across the blood–brain barrier

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Pseudocolored non-primate human cerebellum shows brain exposure of a systemically delivered BrainCAB-shuttled antibody. BrainCAB uses a small-molecule carbonic anhydrase IV binder to promote blood-brain barrier transport of large biomolecular cargos. Credit: Gradinaru Lab / Caltech

The blood–brain barrier (BBB) is a protective filter that lines the brain’s blood vessels and is notoriously…

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