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Mouse study identifies bile acid pathways that may reduce liver fat

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Researchers treated high-fat diet-fed mice with HDCA and found that it reduced liver fat accumulation through two pathways involving iNKT cells/IFN-γ and GLP-1. HDCA increased liver iNKT cells and IFN-γ signaling, which increased PPARα activity and fatty-acid oxidation (FAO). It also increased GLP-1 signaling, which increased PPARα activity and FAO, helping reduce fat accumulation in the liver. Credit: Dr. Eunyong…

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