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Nasal spray made from stem cell-derived vesicles could treat Alzheimer’s disease

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Intranasal administration of extracellular vesicles from human induced pluripotent stem cell-derived neural stem cells (hiPSC-NSC-EVs) altered the expression of genes linked to disease-associated microglia (DAM) and NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome activation in 5xFAD mice microglia when observed 72 h post-EVs…

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