HomeHealth NewsChromatin accessibility maps reveal how stem cells drive myelodysplastic syndrome progression

Chromatin accessibility maps reveal how stem cells drive myelodysplastic syndrome progression

December 14, 2025

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Genome-wide chromatin accessibility profiling reveals how myelodysplastic syndrome (MDS) stem cells progressively lose normal stem-cell features and acquire myeloid progenitor-like characteristics. These chromatin shifts help map the molecular trajectory of disease progression and form the basis of a chromatin-derived “progenitor score” that reflects MDS severity. Credit: Professor Atsushi Iwama / The Institute of…

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