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Three-drug combo targets immune suppression to overcome melanoma resistance

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Figure 5b from the paper shows the difference between tumors treated with just an antibody and vehicle (solution) or with trametinib and rigosertib and a CD40 agonist. Credit: Nature Communications (2026). DOI: 10.1038/s41467-025-67315-1

For patients with advanced melanoma without BRAF mutation who no longer respond to immune…

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