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How a chemical reaction triggers brain inflammation in Alzheimer’s disease

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Connections between nerve cells in the brain (synapses, labeled green) usually deteriorate in the brains of Alzheimer’s mouse models (left). Stopping the formation of a molecule known as SNO-STING protects these connections between cells (right). Credit: Scripps Research.

The brain has its own immune system, which detects threats and mounts a defense. A growing body of evidence has shown that…

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