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Why only some patients get liver disease: New protein pathway may help forecast alpha1-antitrypsin outcomes

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Researchers at WashU Medicine have identified a previously unknown biological process that may help explain why only a subset of patients with alpha1-antitrypsin deficiency develop liver disease. In this section of liver from a mouse modeling the genetic disorder, darker pink areas show the accumulation of a protein associated with liver disease in some patients. Credit: David Rudnick/WashU

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